methyl isobutyl ketone cancer

h�bbd``b`:$�A��` � FLAMMABLE LIQUID AND VAPOR. Store at Room Temperature. Methyl isobutyl ketone (MIBK) CASRN 108-10-1 | DTXSID5021889. In female rats, there were increases in the incidence of CPN in all exposure concentrations and in the severity at 1800 ppm, indicating that CPN was increased by mechanisms in addition to those related to α2μ-globulin.

HARMFUL IF INHALED. 0000010245 00000 n In order to evaluate the potential of MIBK to induce toxic and carcinogenic effects following chronic exposure, groups of 50 male and 50 female F344/N rats and B6C3F1 mice were exposed to MIBK at concentrations of 0, 450, 900, or 1800 ppm by inhalation, 6 h/day, 5 days per week for 2 years. - [4-Methyl-2-pentanone ; Methylisobutyl ketone, MIBK]:100ppm 410mg/m3 B. 0000004218 00000 n

Body weight gains were decreased in male rats at 900 and 1800 ppm and in female mice at 1800 ppm. 0000005580 00000 n In male rats, there was increased mineralization of the renal papilla at all exposure concentrations. trailer endstream endobj 30 0 obj<.

51 0 obj <>/Filter/FlateDecode/ID[<31346B5560A2D34D9FB31D8E5A592020><67A77A2069B32D46BC0A944AF1F9F267>]/Index[31 38]/Info 30 0 R/Length 92/Prev 94310/Root 32 0 R/Size 69/Type/XRef/W[1 2 1]>>stream (4) EPA has classified methyl isobutyl ketone as a Group D, not classifiable as to human carcinogenicity.

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EPA/635/R-03/002 TOXICOLOGICAL REVIEW OF METHYL ISOBUTYL KETONE (CAS No. 0000004475 00000 n

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The primary targets of MIBK toxicity and carcinogenicity were the kidney in rats and the liver in mice. There were also increases in renal tubule hyperplasia at all exposure concentrations, and in adenoma and adenoma or carcinoma (combined) at 1800 ppm; these lesions are thought to represent a continuum in the progression of proliferative lesions in renal tubule epithelium. �k��j�ŞK�������ϼ8 )ӣOΊ*4�.s�,CU�T¬_%r�8O"4Ψ��V�8���y���!�f����|�/=c�l �5�p ����*q�����f�Cp�T���薚��v�:�p�46��B&f���x��X$)�VҬ�М ��0�'�Lc�W� �S�I��֭� ~�T����=���{���9 h�b```"SVi&~�g`��0p4�9�8��!Y�`�D�%��}�������Lj �0�@E|���@Z��������-�8!��P�������uBp�����l�鎧u�_��g����� w�c^D�Q 0000004813 00000 n 0

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Engineering controls - A system of local and/or general exhaust is recommended … Methyl Isobutyl Ketone 108- 10 -1 90 - 100% Yes 3. By continuing you agree to the use of cookies.

MAY FORM EXPLOSIVE PEROXIDES IN AIR. 0000053428 00000 n 0000049907 00000 n There were renal mesenchymal tumors, which have not been observed in historical control animals, in two female rats at 1800 ppm. 29 30 There were also treatment-related increases in multiple adenomas in both sexes. 68 0 obj <>stream 0000009418 00000 n

0000034054 00000 n � BU/ 0000000913 00000 n Methyl isobutyl ketone (MIBK) is the organic compound with the formula (CH 3) 2 CHCH 2 C(O)CH 3.This colourless liquid, a ketone, is used as a solvent for gums, resins, paints, varnishes, lacquers, and …

It is used as a solvent.

0000002277 00000 n %PDF-1.5 %���� Safety Data Sheet >. These increases may have resulted from the increased severity of CPN, either through α2μ-globulin-dependent or -independent mechanisms. Inhalation of vapors is the most likely route of exposure in the work place. NIOSH: The recommended airborne exposure limit is ... Cancer Hazard * According to the information presently available to the New Jersey Department of Health and Senior Services, Methyl Copyright © 2020 Elsevier B.V. or its licensors or contributors. 108-10-1) In Support of Summary Information on the Integrated Risk Information System (IRIS) Containers which are opened must be carefully resealed and kept upright to prevent leakage. 0000001794 00000 n �����8;I.

@�@���e� ����J�'��q�@D�8"Z���(�p �����Ȱ�e`����G� 5� 5 Present address: Syngenta Crop Protection Inc., Greensboro, NC 27409, United States. Methyl isobutyl ketone CAS RN: 108-10-1 Storage Conditions.

%PDF-1.6 %���� 31 0 obj <> endobj 0000000016 00000 n 0000003656 00000 n 0000002756 00000 n h��Zmo��+��{| �(N4ia�M��~P��#@��\����3���Nc�m�������J� q��/2�_�0H�q|H.C��R�R��+y�~��s@���(A����K����C-���) �|�9y�`��������bx�9y��_��\\^�@�/'OOnΗ�!�{��������my��|v�À�m�\n�.���cL�����7�/Ϯ6�=���ɰ�}��|���v��ϻ/Nwg����l�6�����zVk��$���^}��|��n��,9��dۦ�Xǚ|ry�����ݐ��O?��yz�}5eW��h?q�1�F�ݧ4J�Af[���j�dG����^n7z}~yq���NϮ�����B�n��ή.ϟ\���ns�۾�Z;ג���W���&���-���g�NN�܁ʳ�o��Ϸ�[�����r�����������̓'7?lnN_�zu�}II8�������Wg�6ˢ#VhlvdK8�L�=�o'7���� Methyl Isobutyl Ketone is a colorless liquid with a pleasant odor. 0

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